Hyperplastic polyposis syndrome: endoscopic imaging, phenotypic charcteristics and molecular pathways

Phenotypic characteristics Hyperplastic polyposis syndrome (HPS) is a heterogeneous condition involving colorectal serrated polyps and is associated with an increased colorectal cancer (CRC) risk. We evaluated the clinicopathological features of HPS patients and their first-degree relatives. Previously published case series report CRC at clinical presentation in up to 50% of HPS patients. We analyzed the risk of developing CRC after HPS diagnosis and which variables are associated with CRC in a large multi-centre cohort of HPS patients undergoing endoscopic surveillance. Furthermore, the prevalence of polyps and CRC in firstdegree relatives is described and compared with the background prevalence in the general population.